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Does grapefruit juice affect atorvastatin?

Does grapefruit juice affect atorvastatin?

Grapefruit and other juice products appear to interfere with an enzyme the body uses to break down certain statins. Included are Zocor (simvastatin), lovastatin (Mevacor, Altoprev) and to a lesser extent Lipitor (atorvastatin). Grapefruit juice may increase the amount of drug that remains in the body.

What medicines don’t work with grapefruit?

Some statins ( cholesterol-lowering drugs): lovastatin ( Mevacor ),atorvastatin ( Lipitor ),simvastatin ( Zocor ).

  • Antihistamines: fexofenadine (Allegra)
  • Some type of calcium channel blockers ( blood pressure drugs ): felodipine ( Plendil ),nifedipine ( Adalat,Afeditab CR,Procardia)
  • Certain psychiatric drugs: buspirone,triazolam ( Halcion ),carbamazepine ( Tegretol ),diazepam ( Valium ),midazolam ( Versed ),sertraline ( Zoloft)
  • Some immunosuppressants: cyclosporine ( Neoral ),tacrolimus ( Prograf)
  • Certain pain medications: methadone
  • The impotence drug (erectile dysfunction): sildenafil (Viagra)
  • Some HIV medication: saquinavir ( Invirase)
  • Some antiarrhythmics: amiodarone ( Cordarone,Nexterone,Pacerone)
  • What medicines are affected by grapefruit?

    Dear Dr. Roach: For many years,I have heard that grapefruit products interfere with medication that one is taking.

  • Answer: Grapefruit juice reduces the activity of an enzyme called cytochrome P 3A4,which metabolizes many drugs.
  • Dear Dr.
  • Answer: There‚Äôs a little bit of truth there.
  • What medicines should I avoid with grapefruit?

    Some cancer drugs,antibiotics,or heart medications may lead to an abnormal heart rhythm when combined with grapefruit.

  • Muscle and kidney damage can be a serious side effect with statins used for lowering cholesterol.
  • Some immunosuppressants used after organ transplants have been reported to cause kidney damage.