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Which chemotherapy drugs cause hepatotoxicity?

Which chemotherapy drugs cause hepatotoxicity?

The major chemotherapeutic agents in this group include methotrexate, sorafenib, dactinomycin, ifosfamide, gemcitabine, etoposide, irinotecan, procarbazine, 6-mercaptopurine, cytarabine, crizotinib, and cyclophosphamide.

Can Gemzar cause liver damage?

Gemcitabine is associated with a high rate of transient serum enzyme elevations during therapy but is a very rare cause of acute, clinically apparent liver injury.

What is Hy’s Law criteria?

Hy’s law is a rule of thumb that a patient is at high risk of a fatal drug-induced liver injury if given a medication that causes hepatocellular injury (not Hepatobiliary injury) with jaundice. The law is based on observations by Hy Zimmerman, a major scholar of drug-induced liver injury.

What does hepatotoxicity mean?

Articles On Toxic Liver Disease Toxic liver disease is damage to your liver. It’s also called hepatotoxicity or toxic hepatitis. It can cause serious symptoms or liver damage if you don’t get help. Medications, herbal supplements, chemicals, solvents, and alcohol are all possible causes of hepatotoxicity.

Can chemo damage liver be reversed?

Chemotherapy-induced liver damage in patients with cancer may occur during chemotherapy or after the total course. Although liver function impairment may be reversed in some patients after treatment, abnormal liver function may lead to an interruption of anti-tumor therapy and jeopardize the prognosis of patients [20].

How can I protect my liver from chemo?

If you are at risk of liver damage following cancer treatment, you can help lower the risk by keeping your liver healthy.

  1. Get immunized against hepatitis A and B.
  2. Avoid alcohol or limit the amount you drink.
  3. Drink plenty of water.
  4. Eat a well-balanced diet and less fatty, salty, smoked and cured foods.

Is gemcitabine a prodrug?

Gemcitabine is a cytidine analog with two fluorine atoms replacing the hydroxyl on the ribose. As a prodrug, gemcitabine is transformed into its active metabolites that work by replacing the building blocks of nucleic acids during DNA elongation, arresting tumour growth and promoting apoptosis of malignant cells.

What is Grade 3 ALT increase?

However, it should be stressed that these terms usually overestimate the severity of drug induced liver injury, as ALT levels of 5 to 20 times the upper limit of normal (~400 to 800 U/L) without symptoms or jaundice cannot be considered severe hepatotoxicity, and should instead be referred to as “Grade 3 ALT elevations …