What drugs cause drug induced myopathy?

What drugs cause drug induced myopathy?

Many drugs can induce vacuolar myopathy (colchicine, chloroquine, amiodarone, cyclosporin, drugs causing hypokalaemia and lipid-lowering agents), some others cause a mitochondrial myopathy (zidovudine) or a necrotizing myopathy as seen with vincristine.

How is drug induced myopathy treated?

Corticosteroids are the mainstay of treatment, but these drugs are burdened by several side effects. Thus, additional treatment based on immunosuppressive agents, especially azathioprine, methotrexate, mycophenolate mofetil and cyclosporine, is often needed.

How does colchicine cause rhabdomyolysis?

The co-administration of additional drugs to colchicine constitute another risk factor that increases myotoxicity and rhabdomyolysis, either through inhibition of colchicine clearance (erythromycin or cyclosporine) or through their additional myotoxic effect (corticosteroids and statins).

How do drugs cause rhabdomyolysis?

Any drug which directly or indirectly impairs the production or use of adenosine triphosphate (ATP) by skeletal muscle, or increases energy requirements so as to exceed ATP production, can cause rhabdomyolysis.

Can colchicine cause myopathy?

Colchicine can also produce myopathy, and rhabdomyolysis has been reported in severe cases. As with statins, muscle damage often occurs when CYP3A4 inhibitors cause large increases in colchicine plasma concentrations.

Does colchicine cause muscle weakness?

Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy. The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.

What is the best treatment for rhabdomyolysis?

To treat rhabdomyolysis, your doctor will first give you fluids and electrolytes intravenously (through a vein). These IV fluids flush the toxins from your system. You may need to stay in the hospital for a few days. After treatment, physical therapy can help you strengthen your muscles after an initial period of rest.

Which class of drug can cause rhabdomyolysis?

Statins are the only class of drugs that commonly lead to skeletal muscle injury, in particular when combined with drugs interacting on the level of pharmacokinetics.

Can colchicine cause muscle weakness?

What drugs increase CK levels?

Drugs that can increase CPK measurements include the following:

• Alcohol.
• Amphotericin B.
• Certain anesthetics.
• Cocaine.
• Fibrate drugs.
• Statins.
• Steroids, such as dexamethasone.