What is kanamycin used for?
Kanamycin injection is used to treat serious bacterial infections in many different parts of the body. This medicine is for short-term use only (usually 7 to 10 days). Kanamycin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth.
What are the side effects of kanamycin?
Common side effects of Kantrex (kanamycin) include pain or irritation where the injection was given, skin rash or itching, hives, allergic reaction, headache, fever, nausea, or vomiting. Dosage of Kantrex is based on the patient’s body weight.
How do you inject kanamycin?
Intramuscular Route. Inject deeply into the upper outer quadrant of the gluteal muscle. The recommended dose for adults or children is 15 mg/kg/day in two equally divided dosages administered at equally divided intervals; ie, 7.5 mg/kg q 12h.
Which is the highly toxic aminoglycosides?
However, the aminoglycosides displayed marked differences in the threshold dose required to produce toxic reactions, permitting the following ordering of toxicity: (most toxic) gentamicin greater than netilmicin = tobramycin greater than amikacin = kanamycin (least toxic).
What kind of antibiotic is kanamycin?
Kanamycin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.
What bacteria is kanamycin effective against?
Kanamycin A is similar to streptomycin and neomycines, and it possesses a broad spectrum of antimicrobial action. It is active with respect to most Gram-positive and Gram-negative microorganisms (staphylococci, colon bacillus, klebisella, Fridlender’s bacillus, proteus, shigella, salmonella).
Can humans take kanamycin?
This medicine may cause kidney problems, nerve problems, and hearing problems (like long-lasting hearing loss). This could even happen at normal doses. The risk of these problems may be higher if you already have kidney or hearing problems, if you get high doses of kanamycin, or if you get kanamycin for a long time.
Is kanamycin the same as ampicillin?
The inhibition blocks the binary fission and leads to cell lysis, ampicillin is a BACTERICIDAL agent. On the other side kanamycin inhibits the protein synthesis by blocking the 30s subunit of the ribosome. Kanamycin acts as an BACTERISTATIC agent it arrests the growth and proliferation of cells.
Is kanamycin used on TB?
Kanamycin is an aminoglycoside antibiotic used to treat several bacterial infections. It is used to treat multi-drug resistant TB as well. Kanamycin, discovered in 1957, is used as part of a treatment regimen, usually involving 5 medicines, to treat MDR TB. It is part of a group of medicines called injectables.
How does aminoglycosides affect the kidney?
Chronic kidney disease. Regular courses of aminoglycoside antibiotics may cause subclinical kidney damage leading to chronic kidney disease (CKD). This can manifest at the level of the glomerulus (causing decreased glomerular filtration rate, GFR) and the tubules (causing altered excretion of electrolytes).
What bacteria is kanamycin resistant?
Streptomyces kanamyceticus ISP5500, S. fradiae ISP5063 and S. griseus ISP5236, which produce kanamycin, neomycin or streptomycin respectively, were highly resistant to the antibiotics they produced. Polyphenylalanine synthesis in cell free systems was also resistant to the action of the antibiotics.