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Who developed the rVSV-ZEBOV vaccine?

Who developed the rVSV-ZEBOV vaccine?

With an exceptional background in hemorrhagic fever virus of the Filoviridae family, within three years Feldmann and his colleagues developed an Ebola vaccine candidate: rVSV-ZEBOV10. NML later became part of the Public Health Agency of Canada (PHAC).

How quickly was the Ebola vaccine developed?

The period of 5 years from the start of Phase 1 trials in Oct 2014 to the approval of this vaccine in Nov 2019, was much faster than the typical 10–15 year timeline for vaccine development and approval4. A timeline of the key activities in the development of this Ebola vaccine is summarized in Fig.

How was Ebola vaccine developed?

The rVSV-ZEBOV vaccine uses a genetically engineered version of vesicular stomatitis virus (VSV), an animal virus that primarily affects cattle, to carry an Ebola virus gene insert. Experts at the Public Health Agency of Canada originally developed the vaccine, which is now licensed to Merck.

Is rVSV-ZEBOV effective?

Notably, the rVSV-ZEBOV vaccine was shown to provide 100% efficacy (95% CI 68.9–100.0, p = 0.0045) when used in Guinea in a ring vaccination, open-label, cluster-randomized Phase III clinical trial4.

When did the FDA approve the Ebola vaccine?

Vaccine: On December 19, 2019, FDA announced the approval of Ervebo, the first FDA-approved vaccine for the prevention of EVD, caused by Zaire ebolavirus in individuals 18 years of age and older.

How long did it take to cure Ebola?

It was concerning because the outbreak was on the river, in an area where people traveled and traded. But the virus was stopped after three months, and 4,000 vaccinations. Between April and June, 33 people died of Ebola.

What is rVSV-Zebov vaccine?

Recombinant vesicular stomatitis virus–Zaire Ebola virus (rVSV-ZEBOV), also known as Ebola Zaire vaccine live and sold under the brand name Ervebo, is an Ebola vaccine for adults that prevents Ebola caused by the Zaire ebolavirus. When used in ring vaccination, rVSV-ZEBOV has shown a high level of protection.

What is rVSV-ZEBOV vaccine?

Is there a cure or vaccine for Ebola?

There’s no cure for Ebola, though researchers are working on it. There are two drug treatments which have been approved for treating Ebola. Inmazeb is a mixture of three monoclonal antibodies (atoltivimab, maftivimab, and odesivimab-ebgn).

Is there a cure for Ebola yet?

Does Ebola virus has a vaccine?

The U.S. Food and Drug Administration (FDA) approved the Ebola vaccine rVSV-ZEBOV (called Ervebo®) on December 19, 2019. This is the first FDA-approved vaccine for Ebola.